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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genetic and epigenetic interactions in a mouse model for autism

Principal Investigator

Principal Investigator

Carpenter, Ellen

Description

Description

In this study, Dr. Carpenter and colleagues will examine the interaction between a specific gene and an environmental factor in the development of autistic-like behaviors in a mouse model. The reelin gene is a candidate genetic factor for autism and is important for the development of the cerebral cortex and cerebellum. Mice with reduced levels of expression of this gene have neurodevelopmental defects which result in behavioral abnormalities. This research will examine the effects of an environmental factor hypothesized to be a risk factor for autism (organophosphate exposure during the prenatal period) on the development of autistic behaviors in mice which express low levels of the protein encoded by the reelin gene. It will also determine whether reduced reelin expression in combination with organophosphate exposure leads to changes in the anatomy of brain regions associated with these behaviors.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

60000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.

Project Link

Project Link

Genetic and epigenetic interactions in a mouse model for autism (External web link)

Institution

Institution

David Geffen School of Medicine at University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

2552

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Genetic and epigenetic interactions in a mouse model for autism | 60000 | 2008 | 2552

 
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