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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Behavioral and genetic biomarker development for autism and related disorders

Principal Investigator

Principal Investigator

Brzustowicz, Linda

Description

Description

While it is clear that autism has a strong inherited genetic component, many large scale genetic studies that have relied only on a general ASD diagnosis or information collected only on affected individuals have had limited success in identifying risk alleles. An alternative is to examine behavioral biomarkers, especially for language ability, to assist with gene mapping, and to extend the data collection beyond just the individual diagnosed with autism to include family members that also exhibit a language delay. This project will use this approach by utilizing an existing database that contains clinical and genetic information for people with autism and all their family members in order to identify biomarkers for risk of autism. Potential behavioral biomarkers will be validated and candidate genes will be examined for DNA variations in sequence or copy number. Overall, the combined analysis of behavioral and genetic biomarkers will enable development of more accurate models for the prediction of risk for autism spectrum disorders.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

499543

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Behavioral and genetic biomarker development for autism and related disorders (External web link)

Institution

Institution

Rutgers, The State University of New Jersey - New Brunswick

State/Country

State/Country

New Jersey

Project Number

Project Number

1RC1MH088288-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Behavioral and genetic biomarker development for autism and related disorders | 494132 | 2010 | 5RC1MH088288-02

 
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