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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Identification and functional assessment of autism susceptibility genes

Principal Investigator

Principal Investigator

Brzustowicz, Linda

Description

Description

Although there is strong evidence of a genetic contribution to the cause of autism spectrum disorders (ASD), the isolation of specific causative genetic defects has been difficult. This project will use existing DNA and clinical data from the Autism Genetic Resource Exchange (AGRE) and National Institute of Mental Health (NIMH) repositories to search for ASD susceptibility genes. Genotype analysis, mapping of single nucleotide polymorphisms (changes in a single DNA codon), and linkage studies will be used to identify candidate genes. Post-mortem human tissue, neuronal cultures, and mouse models will then be used to assess whether associated alleles in different locations on the chromosome (haplotypes) functionally alter autism candidate genes. These experiments are expected to identify ASD-associated alleles for multiple genes, and the mouse models that are generated for some of the associated haplotypes can be used as future models for developmental, behavioral, and toxicological experiments.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

478257

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Identification and functional assessment of autism susceptibility genes (External web link)

Institution

Institution

Rutgers, The State University of New Jersey - New Brunswick

State/Country

State/Country

New Jersey

Project Number

Project Number

5R01MH076435-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Identification and functional assessment of autism susceptibility genes - 1 | 401474 | 2008 | R01MH076435-04

 
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