This is an individual National Research Service Award for post-doctoral research training, which provides support to promising fellowship applicants with the potential to become productive, independent investigators in scientific health-related research fields. In this proposed study, the fellow will examine the influence of maternal illness on the health of offspring. Maternal illness has been associated with a number of problems in brain development in the child, including autism and schizophrenia. The fellow will study a mouse model in which illness and inflammation in the pregnant mother has significant effects on the number and timing of neurons being born in the fetal brain. The goal of this study is to examine the mechanisms by which fetal brain development is altered in this model, focusing on the role of a single inflammatory molecule (TNF-alpha), which could be clinically targeted to prevent developmental diseases.