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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Building a selective inhibitory control tone in autism: An rTMS study

Principal Investigator

Principal Investigator

Casanova, Manuel

Description

Description

Some reports have shown that autism is associated with structural abnormalities in the brain. A GABAergic interneuron called a double-bouquet cell usually protects the areas around minicolumns, which help give the cortical area of the brain structure. Having too many axon terminals, dendrites, and other cell matter too close to the minicolums has been associated with autism. This study will try to strengthen double-bouquet cells to increase their power to inhibit encroachment on the space around the minicolumns. This will be done in autistic patients and controls by inducing electrical current into the double-bouquet cells (by creating a magnetic field) through Transcranial Magnetic Stimulation (TMS). Outcome measures will include behavioral and electrophysiological measures. The results of the proposed study will help understand the specific social communication and cognitive deficits associated with developmental abnormalities of functions within cortical circuitry, and thereby contribute to understanding the brain substrates of behavioral dysfunctions typical for autism. The research represents a new development in combining TMS with functional outcome measures (cognitive event-related potential (ERP), EEG), using TMS as a theory-guided psychiatric therapy in autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

222000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

4O. Not specific to Question 4 objectives

Project Link

Project Link

Building a selective inhibitory control tone in autism: An rTMS study (External web link)

Institution

Institution

University of Louisville

State/Country

State/Country

Kentucky

Project Number

Project Number

1R01MH086784-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Building a selective inhibitory control tone in autism: An rTMS study | 222000 | 2010 | 5R01MH086784-02

 
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