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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Ethnicity and the elucidation of autism endophenotypes

Principal Investigator

Principal Investigator

Constantino, John

Description

Description

Research has focused on identifying subgroups of people with autism, or "endophenotypes," in order to accelerate the discovery of autism's genetic basis. People with the same endophenotype share certain traits, which may include morphological, physiological or behavioral features. This research project explores a candidate endophenotype based on motor ability. Dr. Constantino's fellow will evaluate the coordination of movement in school-aged children with autism and their siblings. The subjects will come from a well-characterized sample of sibling pairs that either share autism (concordant) or do not share autism (discordant), and this sample includes both Caucasian and African-American families. By analyzing how motor abilities vary among autistic and non-autistic siblings, this work will test the reliability of this candidate endophenotype. In addition, the early development of motor abilities will be studied in a different sample of high-risk infant siblings of individuals with autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

61000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Project Link

Project Link

Ethnicity and the elucidation of autism endophenotypes (External web link)

Institution

Institution

Washington University in St. Louis

State/Country

State/Country

Missouri

Project Number

Project Number

2306

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Ethnicity and the elucidation of autism endophenotypes | 0 | 2010 | 2306
Ethnicity and the elucidation of autism endophenotypes | 61000 | 2008 | 2306

 
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