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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Role of excitation and inhibition in Rett syndrome

Principal Investigator

Principal Investigator

Chao, Hsiao-Tuan

Description

Description

This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. Rett syndrome (RTT) is a progressive neurodevelopmental disease caused predominantly by loss-of-function mutations in the X-linked gene encoding the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2). Recent reports reveal that producing too much MeCP2 is also detrimental to neurological function. This project will examine the neurophysiological properties of neurons upon loss or doubling of MeCP2, develop and characterize conditional MeCP2 knockout mouse models specific to excitatory and inhibitory neurons, and assess their behavioral and neurophysiological phenotypes. The study will help elucidate the impact of altered MeCP2 levels on neuronal function and identify the contribution of global excitatory and inhibitory neuronal activity to Rett syndrome phenotypes. This research will give insight into RTT pathogenesis and provide new target pathways for investigating potential therapeutic interventions.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

32922

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Role of excitation and inhibition in Rett syndrome (External web link)

Institution

Institution

Baylor College of Medicine

State/Country

State/Country

Texas

Project Number

Project Number

5F31MH078678-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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