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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Synaptic plasticity, memory and social behavior

Principal Investigator

Principal Investigator

Chevere-Torres, Itzamarie

Description

Description

This is an individual National Research Service Award for post-doctoral research training, which provides support for promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields. This proposal is focused on studying the signaling pathways that regulate translation in a mouse model of tuberous sclerosis complex (TSC). The hypothesis is that inhibition of the TSC1/TSC2 protein complex will result in alterations in hippocampal synaptic plasticity, hippocampus-dependent memory, and social behavior via upregulated signaling in the mTOR pathway. Electrophysiological, behavioral, and biochemical analyses will be used to determine whether protein synthesis-dependent synaptic plasticity and mTOR signaling are altered in images of hippocampal brain slices, as well as whether these mice are impaired in hippocampus-dependent learning and memory and social interaction. These studies are among the few to examine the dysfunction of molecular signaling that controls translation and whether they are correlated with altered synaptic plasticity and behavior that would be consistent with autism and mental retardation.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

50054

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

Synaptic plasticity, memory and social behavior (External web link)

Institution

Institution

New York University

State/Country

State/Country

New York

Project Number

Project Number

1F32MH085489-01A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Synaptic plasticity, memory and social behavior | 52154 | 2010 | 5F32MH085489-02

 
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