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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Pupil size and circadian salivary variations in autism spectrum disorder

Principal Investigator

Principal Investigator

Colombo, John

Description

Description

Atypical baseline levels of autonomic activity and sleep difficulties have been previously reported in persons with autism and indicate a heightened level of sympathetic activity. This project seeks to determine the neurochemical systems involved in producing atypical autonomic responses in children with autism. In this study, researchers will measure circadian rhythms of cortisol and alpha-amylase and their relationship to tonic pupil size in two to five year old children with autism spectrum disorder (ASD). These measures will be taken on two separate days on a group of 20 children with a diagnosed ASD, 20 children with Down syndrome, and 20 typically-developing children. The determination of the neurochemical component responsible for atypical autonomic responses could lead to identification of a neural impairment in autism that is potentially primary to other impairments and could lead to pharmacological and/or behavioral interventions targeted at preventing this impairment from causing a cascade of effects. If successful, the development of non-invasive autonomic and salivary measures could also provide easy-to-use markers for screening and detecting autism at a very early age.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

70138

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

Pupil size and circadian salivary variations in autism spectrum disorder (External web link)

Institution

Institution

University of Kansas

State/Country

State/Country

Kansas

Project Number

Project Number

1R03MH084061-01A1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Pupil size and circadian salivary variations in autism spectrum disorder | 70035 | 2010 | 5R03MH084061-02

 
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