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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

ACE Center: Genetics of serotonin in autism: Neurochemical and clinical

Principal Investigator

Principal Investigator

Cook, Edwin

Description

Description

This grant provides support for an NIH Autism Center of Excellence (ACE). Neurochemical, behavioral, and genetic evidence implicate serotonin dysfunction in autism, specifically in restricted and repetitive behaviors (RRBs). Recently described mutations in a serotonin transporter gene reveal a common pattern of elevated serotonin transporter activity and a phenotype of autism with RRBs or obsessive compulsive disorder. In this research project, twenty-five serotonin related genes will be studied in 250 ASD children rigorously screened using ACE and Autism Diagnostic Interview, Revised (ADI-R) criteria to determine association with autism, specifically for Insistence on Sameness (IS).

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

377577

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

3O. Not specific to Question 3 objectives

Project Link

Project Link

ACE Center: Genetics of serotonin in autism: Neurochemical and clinical (External web link)

Institution

Institution

University of Illinois at Chicago

State/Country

State/Country

Illinois

Project Number

Project Number

5P50HD055751-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

ACE Center: Genetics of serotonin in autism: Neurochemical and clinical endophenotypes | 382540 | 2010 | 5P50HD055751-04

 
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