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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Prenatal exposure to polyfluoroalkyl compounds in the EMA study

Principal Investigator

Principal Investigator

Croen, Lisa

Description

Description

Preliminary research studies have implicated a complex interplay of immunologic and genetic susceptibility factors with environmental exposures as critical elements in the development of autism spectrum disorders (ASD). The primary goal of this study is to identify early biologic markers for ASD in a large case-control study consisting of 1,200 mother-baby pairs (400 with ASD, 400 with mental retardation (MR) but not autism, and 400 general population (GP) controls) with an added family-based component that includes 60 siblings of ASD cases and 60 siblings of MR controls. Researchers will use blood specimens taken during pregnancy to explore the interplay between markers of endocrine function and environmental exposures, including the organic compound polyfluoroalkyl compounds (PFCs), during critical periods of fetal brain development and identify factors that contribute to ASD risk. In the long-term, a better understanding of the underlying biology may suggest appropriate strategies for early intervention and contribute to the eventual prevention of this often devastating and usually life-long disability.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

272062

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.

Project Link

Project Link

Prenatal exposure to polyfluoroalkyl compounds in the EMA study (External web link)

Institution

Institution

Kaiser Foundation Research Institute

State/Country

State/Country

California

Project Number

Project Number

1R01ES019003-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Prenatal exposure to polyfluoroalkyl compounds in the EMA study | 130465 | 2010 | 5R01ES019003-02

 
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