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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A longitudinal 3-D MRSI study of infants at high risk for autism

Principal Investigator

Principal Investigator

Dager, Stephen

Description

Description

This research investigates relationships between brain structural development and autism symptom onset that typically presents between 12 and 24 months of age. This proposal will add brain chemical information (through the use of 3-D Proton Echo Planar Spectroscopic Imaging, or 3D PEPSI) to assess mechanisms of abnormalities in brain growth (regions, tissues, structures, and fiber tracts) that are measured by magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). These measures will be related to clinical features of autism. The addition of 3D PEPSI will allow measurements of brain chemistry in 6 month-old siblings of children diagnosed with autism (high risk) and age-matched infants without a family history of autism (low risk). These infants will be rescanned at 12 and 24 months and clinically assessed for a possible autism diagnosis at 24 months. Brain chemical measures collected as part of this project have the potential to help identify distinct clinical subtypes of autism spectrum disorder (ASD) that may have prognostic and treatment implications. Brain chemical measurements will provide biomarkers that may identify distinct ASD endophenotypes and help elucidate underlying pathophysiological mechanisms responsible for abnormalities in brain development in autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

225553

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LA. Identify behavioral and biological markers that separately, or in combination, accurately identify, before age 2, one or more subtypes of children at risk for developing ASD by 2014. IACC Recommended Budget: $33,300,000 over 5 years.

Project Link

Project Link

A longitudinal 3-D MRSI study of infants at high risk for autism (External web link)

Institution

Institution

University of Washington

State/Country

State/Country

Washington

Project Number

Project Number

1R01HD065283-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

A longitudinal 3-D MRSI study of infants at high risk for autism | 219046 | 2010 | 5R01HD065283-02

 
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