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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment

Principal Investigator

Principal Investigator

DeWitt, Jamie

Description

Description

This project tests the hypothesis that developmental exposure to environmental contaminants perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) may affect the number and/or function of regulatory T cells in mice, which consequently increases autoreactive T cell-induced damage within the brains of exposed offspring and leads to an autistic phenotype in exposed individuals.

Funder

Funder

Department of Defense

Fiscal Year Funding

Fiscal Year Funding

106609

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.

Project Link

Project Link

Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment (External web link)

Institution

Institution

East Carolina University

State/Country

State/Country

North Carolina

Project Number

Project Number

AR093526

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment | 0 | 2010 | AR093526
Immunopathogenesis in autism: Regulatory T cells and autoimmunity in neurodevelopment | 0 | 2011 | AR093526

 
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