The goal of this project is to identify the cell biological phenotypes that underlie autism and other psychiatric disorders, taking advantage of new developments in human stem cell technology. In this study, the researchers will harvest skin fibroblasts from patients with autism and reprogram these cells to generate induced pluripotent stem (iPS) cells, which will then be differentiated into neurons. Numerous cellular, biochemical, and genetic measures will be used to determine the biological "fingerprint" of these cell lines. Researchers will also determine whether deletion, duplication, or mutation of specific genes leads the phenotypes observed in the neurons from each patient. This approach allows the researchers to link the phenotype and genotype of patients with the cell biological defects that give rise to disease. Information learned in this study can be used to develop cell-based assays to both investigate the etiology of the disease and to find new treatments for these untreatable disorders.