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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models

Principal Investigator

Principal Investigator

Dulawa, Stephanie

Description

Description

Sensorimotor gating is a neural mechanism that filters out extra stimuli and processes information that comes in rapid succession. Prepulse inhibition (PPI) is a form of startle plasticity that provides an operational measure of sensorimotor gating. Sensorimotor gating and PPI may be modulated by serotonin transporters (5-HTT), and deficits in this function are observed in obsessive compulsive disorder (OCD) and autism. Evidence has shown that reducing serotonin transporters leads to improvement in perseverative (repetitive) behaviors. This study will use behavioral and genetic mouse models to identify the neural mechanisms by which serotonin transporters (5-HTT) control sensorimotor gating deficits and repetitive behaviors. This approach could lead to novel animal models of the sensorimotor gating deficits and perseverative behaviors in OCD and autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

345375

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (External web link)

Institution

Institution

University of Chicago

State/Country

State/Country

Illinois

Project Number

Project Number

5R01MH079424-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models | 387353 | 2010 | 5R01MH079424-04
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models | 345375 | 2008 | R01MH079424-02
Mechanisms for 5-HTT control of PPI and perseverative behavior using mouse models (supplement) | 6802 | 2010 | 3R01MH079424-03S2

 
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