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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genome-wide environment interaction study for autism: The SEED study

Principal Investigator

Principal Investigator

Fallin, Margaret Danielle

Description

Description

Improving the understanding of gene-environment interaction (GxE) as a causative factor in autism has been identified as a research priority in the NIH Interagency Autism Coordinating Committee's (IACC's) Strategic Plan for Autism Spectrum Disorders (ASD) Research as well as in the IOM's Report on Autism and the Environment. However, empirical investigations of GxE in autism remain scarce. The Study to Explore Early Development (SEED) is a multisite ASD case-control investigation recruiting 900 3-5 year old children with ASDs, 900 typically developing controls, and 900 children with non-autism developmental impairments. This grant will support research on a subset of SEED participants, including 500 autism cases and 500 controls to identify genes whose effects on ASD may vary across environmental exposure categories related to pre-natal infection, maternal medication use, or smoking and drinking during pregnancy. This work will accelerate future efforts centered around gene-environment interaction both in the full set of SEED participants and in other data sets for autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

723953

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

Genome-wide environment interaction study for autism: The SEED study (External web link)

Institution

Institution

Johns Hopkins University

State/Country

State/Country

Maryland

Project Number

Project Number

1R01ES019001-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Genome-wide environment interaction study for autism: The SEED study | 704956 | 2010 | 5R01ES019001-02

 
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