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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Language functioning in optimal outcome children with a history of autism

Principal Investigator

Principal Investigator

Fein, Deborah

Description

Description

Prognosis for children with autism spectrum disorder (ASD) receiving intensive early intervention has improved substantially. A minority of these children appear to reach what may be called "optimal outcome," in which cognitive and adaptive functioning are within normal limits, and they no longer meet criteria for any ASD. While these optimal outcome children regain many normal language functions, preliminary studies show that some language impairments persist. These preliminary results raise the question: what are the underlying neural mechanisms of the striking improvement of cognitive processes in these optimal outcome children? Functional magnetic resonance imaging (fMRI) will be used during tasks of syntax and face processing to address this question, and exploratory analysis of selected structural variables will be examined to see if the most successful intervention appears to operate on a structurally normal brain.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

457153

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2LB. Launch at least three studies which evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015. IACC Recommended Budget: $7,200,000 over 5 years.

Project Link

Project Link

Language functioning in optimal outcome children with a history of autism (External web link)

Institution

Institution

University of Connecticut

State/Country

State/Country

Connecticut

Project Number

Project Number

5R01MH076189-04

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Language functioning in optimal outcome children with a history of autism | 489612 | 2008 | R01MH076189-03

 
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