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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The CHARGE Study: Childhood Autism Risks from Genetics and the Environment

Principal Investigator

Principal Investigator

Hertz-Picciotto, Irva

Description

Description

Despite a strong influence of genetics, environmental factors are likely to play a causal role for many children with ASD. The proposed project will continue an epidemiologic study of the environmental and genetic causes of autism that was initiated under the University of California-Davis Center for Children's Environmental Health (CCEH). This project, known as the CHARGE (Childhood Autism Risks from Genetics and Environment) Study, is a comprehensive, population-based case-control investigation of underlying causes for autism and triggers of regression. Cases are children with autism and two other groups are included: children with developmental delay and children selected at random from the general population. The proposed study will address the possible role of exposures during the preconceptional, gestational, prenatal, and early childhood periods. Environmental exposures to be studied include infections, assisted reproductive technology, medications, pesticides, brominated flame retardants, and metals. Researchers will also evaluate these environmental factors in conjunction with genes involved in xenobiotic metabolism or identified by gene expression pattern results.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

1015021

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SC. Initiate efforts to expand existing large case-control and other studies to enhance capabilities for targeted gene – environment research by 2011. IACC Recommended Budget: $27,800,000 over 5 years.

Project Link

Project Link

The CHARGE Study: Childhood Autism Risks from Genetics and the Environment (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

5R01ES015359-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The CHARGE Study: Childhood Autism Risks from Genetics and the Environment | 1005627 | 2010 | 5R01ES015359-04
The CHARGE Study: Childhood Autism Risks from Genetics and the Environment (supplement) | 1212792 | 2009 | 3R01ES015359-03S1
The CHARGE Study: Childhood Autism Risks from Genetics and the Environment (supplement) | 405700 | 2009 | 3R01ES015359-03S2
The Charge Study: Childhood autism risks from genetics and the environment | 1014318 | 2008 | R01ES015359-02
The Charge Study: Childhood autism risks from genetics and the environment - Supplemental | 100000 | 2008 | R01ES015359-02S1

 
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