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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A systems biology approach to unravel the underlying functional modules of ASD

Principal Investigator

Principal Investigator

Iakoucheva, Lilia

Description

Description

This project will investigate autism spectrum disorder (ASD) from the systems biology perspective with the aim of defining the protein networks and functional modules that are relevant to the disease. To achieve this goal, an integrative approach will be used to build an autism protein-protein interaction network that includes autism risk genes, their brain-expressed splice variants, and mutant transcripts of the genes that are disrupted by the breakpoints of genomic deletions and duplications in autistic patients. The results of this study will increase knowledge of the causes of autism and of cognitive development. The discovery of specific pathways, networks, and modules that functionally connect seemingly unrelated autism candidate genes will help researchers understand the molecular mechanisms of ASD development and identify potential therapeutic targets.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

663063

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3SA. Coordinate and implement the inclusion of approximately 20,000 subjects for genome-wide association studies, as well as a sample of 1,200 for sequencing studies to examine more than 50 candidate genes by 2011. Studies should investigate factors contributing to phenotypic variation across individuals that share an identified genetic variant and stratify subjects according to behavioral, cognitive, and clinical features. IACC Recommended Budget: $43,700,000 over 4 years.

Project Link

Project Link

A systems biology approach to unravel the underlying functional modules of ASD (External web link)

Institution

Institution

University of California, San Diego

State/Country

State/Country

California

Project Number

Project Number

1R01HD065288-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

A systems biology approach to unravel the underlying functional modules of ASD | 655975 | 2010 | 5R01HD065288-02

 
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