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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Understanding the cognitive impact of early life epilepsy

Principal Investigator

Principal Investigator

Jensen, Frances

Description

Description

There is clinical evidence that early life seizures may be one of many precedents for autism, and epilepsy is common in patients with autism, suggesting an interaction between the two processes. In this study, researchers will induce seizure activity in young rats in order to determine whether early life seizures lead to cognitive dysfunction similar to that observed in autism. The researchers will also test whether different drug interventions administered after the seizure can help lessen neuronal damage caused by seizures. This study may uncover crucial biological connections between epilepsy and autism and identify therapeutic agents that could one day be used to treat these overlapping conditions.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

845000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism including seizures/epilepsy, sleep disorders and familial autoimmune disorders by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Understanding the cognitive impact of early life epilepsy (External web link)

Institution

Institution

Children's Hospital Boston

State/Country

State/Country

Massachusetts

Project Number

Project Number

5DP1OD003347-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Understanding the cognitive impact of early life epilepsy | 845000 | 2010 | 5DP1OD003347-04
Understanding the cognitive impact of early life epilepsy | 845000 | 2008 | DP1OD003347-02

 
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