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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Epigenetics, hormones and sex differences in autism incidence

Principal Investigator

Principal Investigator

Rissman, Emile

Description

Description

Across studies, the ratio of males to females affected with autism is approximately 4:1. Basic research on sex differences in behavior has shown that differences in circulating levels of gonadal hormones during fetal and infant development are responsible for most sexual dimorphism in adults. For normal male development to occur, sex hormones like testosterone act through estrogen receptors, which in turn also activate other genes and proteins. The activation of certain genes through the estrogen receptor, then, may partially explain the sex difference. The body produces natural testosterone and estrogen but environmental chemicals may mimic these compounds and produce deleterious effects during development. This study will use estrogen receptor knockout mice to determine sex-differences on many autism-like behaviors in mice as well as to identify genes which are affected by bisphenol A (BPA) in order to identify the mechanism of action of this environmental chemical and whether it may be linked to autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3SF. Initiate studies on at least 10 environmental factors identified in the recommendations from the 2007 IOM report "Autism and the Environment: Challenges and Opportunities for Research" as potential causes of ASD by 2012. Estimated cost $56,000,000 over 2 years.

Project Link

Project Link

Epigenetics, hormones and sex differences in autism incidence (External web link)

Institution

Institution

University of Virginia

State/Country

State/Country

Virginia

Project Number

Project Number

4802

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Epigenetics, hormones and sex differences in autism incidence | 85000 | 2010 | 4802
Epigenetics, hormones and sex differences in autism incidence | 100000 | 2008 | 4802
Epigenetics, hormones and sex differences in autism incidence | 85000 | 2011 | 4802

 
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