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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Visual system connectivity in a high-risk model of autism

Principal Investigator

Principal Investigator

Sahin, Mustafa

Description

Description

Tuberous Sclerosis Complex (TSC) stems from mutations in one of two genes (TSC1 or TSC2), and in mouse models of TSC, Dr. Sahin's lab has found aberrant axon growth, targeting, and myelination in the brain, which would result in mis-wiring between neurons. This fits with the growing evidence for disrupted neuronal connectivity in autism. In this research project, Dr. Sahin's post-doctoral fellow will investigate how TSC1/2 gene products regulate axon guidance, myelination, and circuit formation in the brain. Specifically, the molecular mechanisms of axon guidance, which involves interactions between TSC proteins and Eph receptors, will be analyzed. The study will also characterize the effect TSC1/2 expression has on the myelin-making cells ("oligodendrocytes"). Finally, the study will investigate the full complement of axonal proteins whose expression is controlled by TSC1/2.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

41000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Visual system connectivity in a high-risk model of autism (External web link)

Institution

Institution

Children's Hospital Boston

State/Country

State/Country

Massachusetts

Project Number

Project Number

2151

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Visual system connectivity in a high-risk model of autism | 0 | 2010 | 2151
Visual system connectivity in a high-risk model of autism | 41000 | 2008 | 2151

 
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