This is a supplement to a previously awarded grant with the same title. Differences in culture, socioeconomic status, environmental exposures, access to health care and other factors may influence the expression of the underlying genetic architecture of autism and lead to alterations in prevalence and clinical severity. While most large-scale research programs are disproportionately comprised of Caucasian individuals, these recruitment biases compromise the generalizability of current findings and prevent a systematic evaluation of differences across racial/ethnic groups. Therefore, the need to present researchers with effective strategies for successful inclusion of minorities in research is critical and timely. Effective strategies for the successful recruitment and retention of a representative sample of Latino subjects will be evaluated and developed to meet the recruitment goals of the Center for Genomic and Phenomic studies in Autism at the University of Southern California (USC).