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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Maternal immune activation, cytokines, and the pathogenesis of autism

Principal Investigator

Principal Investigator

McAllister, A. Kimberley

Description

Description

Although a wide range of environmental stimuli have been proposed to play a role in the pathogenesis of autism spectrum disorders (ASDs), many of these stimuli have in common the ability to alter immune function. Since cytokines mediate the immune response, are present in the developing brain, and regulate cortical plasticity and connectivity, factors that alter cytokines during development may lead to changes in synaptic connectivity that contribute to ASD. The goals of this proposal are to use a mouse model of maternal immune activation (MIA) to define the full complement of cytokines that are changed in specific regions of the central nervous system (CNS) of offspring at various postnatal ages following MIA and to determine the effects of those cytokines on connectivity and function in several cortical regions at the relevant postnatal ages.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

378570

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3LC. Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.

Project Link

Project Link

Maternal immune activation, cytokines, and the pathogenesis of autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

1R01MH088879-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Maternal immune activation, cytokines, and the pathogenesis of autism | 382588 | 2010 | 5R01MH088879-02

 
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