Autism Research Database - Strategic Plan Objective Project Details | IACC

Project Element	Element Description
Project Title Project Title	Understanding glutamate signaling defects in autism spectrum disorders
Principal Investigator Principal Investigator	Wang, Tao
Description Description	In the present study, Dr. Wang and colleagues will conduct a high-throughput genetic screen in a cohort of autistic patients, looking for DNA sequence variants in 38 genes known to be involved in glutamate neurotransmission. If the hypothesis that glutamate is involved in autism is correct, they expect to find multiple rare sequence variants of these genes in autistic patients compared to a non-autistic control sample. This research may clarify the role of glutamate in autism as well as identify new genetic risk factors and potential drug targets for the treatment and prevention of autism.
Funder Funder	Autism Speaks
Funding Country Funding Country	United States
Fiscal Year Funding Fiscal Year Funding	$60,000
Current Award Period Current Award Period	na
Strategic Plan Question Strategic Plan Question	Question 3: What Caused This To Happen And Can This Be Prevented?
Strategic Plan Objective Strategic Plan Objective	Identify genetic risk factors in at least 50% of people with ASD by 2014.
Funder’s Project Link Funder’s Project Link	External Project Page
Institution Institution	Johns Hopkins University
Institute Location Institute Location	Maryland
Project Number Project Number	2487
Federal or Private Federal or Private	Private
Received ARRA Funding? Received ARRA Funding?	No
History/Related Projects History/Related Projects	Understanding glutamate signaling defects in autism spectrum disorders \| $0.00 \| 2010 \| 2487 Understanding glutamate signaling defects in autism spectrum disorders \| $60,000.00 \| 2008 \| 2487

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