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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A preclinical model for determining the role of AVPR1A in autism spectrum disorders

Principal Investigator

Principal Investigator

Charles, Rhonda

Description

Description

Numerous studies, including human genetic and animal model studies, have shown that the neuropeptide arginine vasopressin (AVP) and its receptor arginine vasopressin receptor 1A (AVPR1A) play an important role in regulating behaviors associated with autism spectrum disorders (ASD). Due to the interspecies differences in AVPR1A receptor pharmacology and expression between mice and humans, studies of this receptor in rodents offer limited translation to human studies. This project proposes that generating a mouse expressing only the human form of AVPR1A will provide a more relevant in vivo system in which we can better understand the biology of the human AVPR1A receptor, its role in modulating behaviors associated with ASDs and the relevance of preclinical therapeutics targeting the receptor.

Funder

Funder

Autism Science Foundation

Fiscal Year Funding

Fiscal Year Funding

30000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

No link available.

Institution

Institution

Mount Sinai School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

Project number unavailable

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A preclinical model for determining the role of AVPR1A in autism spectrum disorders | 0 | 2010 | n/a

 
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