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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Olfactory abnormalities in the modeling of Rett syndrome

Principal Investigator

Principal Investigator

Ronnett, Gabriele

Description

Description

Rett Syndrome (RTT) is an autism spectrum disorder (ASD) that results in mental retardation, motor dysfunction, seizures, and features of autism. RTT is caused by mutation of MeCP2, a gene that affects brain gene expression, and a type of mutation that may underlie many ASDs. Little is known about the specific neurodevelopmental defects that underlie the complex clinical course of RTT. This research will use the olfactory system and mouse models of MeCP2 mutation to define the mechanisms that underlie the biological defects incurred by MeCP2 dysfunction to clarify the basis for neuronal compromise in ASDs.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

358750

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Olfactory abnormalities in the modeling of Rett syndrome (External web link)

Institution

Institution

Johns Hopkins University

State/Country

State/Country

Maryland

Project Number

Project Number

2R01NS041079-06A2

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Olfactory abnormalities in the modeling of Rett syndrome | 355163 | 2010 | 5R01NS041079-07

 
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