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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Sex differences in early brain development: Brain development in Turner syndrome

Principal Investigator

Principal Investigator

Santelli, Rebecca Knickmeyer

Description

Description

This is a mentored research scientist development award to support an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. The trainee will study developmental mechanisms in the autism-related disorder Turner syndrome, a well-defined genetic disorder resulting from the partial or complete loss of one of the sex chromosomes. Currently, very little is known about sexual dimorphism in early development, and it is unclear why autism is more prevalent in males than females, though researchers have hypothesized X- chromosome effects and early exposure to gonadal hormones may play a causal role. In this longitudinal study, brain imaging techniques like magnetic resonance imaging (MRI) will be used to characterize brain development in typically developing children and children with Turner syndrome followed from birth to 2 years of age. Results will provide new information on brain-specific sex differences in the developing brain and a better understanding of brain abnormalities in Turner syndrome.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

150049

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Sex differences in early brain development: Brain development in Turner syndrome (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

5K01MH083045-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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