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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Gene expression and immune cell function in mothers of children with autism

Principal Investigator

Principal Investigator

Sharp, Frank

Description

Description

It is possible that an aberrant immune response in mothers during vulnerable, critical periods of neurodevelopment could produce neuronal injury in the fetal or neonatal brain and produce long-term neurological dysfunction characteristic of autism. In this study, researchers will examine several quantifiable biological signatures of immune cells in blood from mothers of children with autism, including RNA levels of immune molecules, functional assays of white blood cells, and the presence of antibodies directed to fetal-brain proteins. Findings from this study could help in identifying a subgroup of mothers of children with autism who share a specific immune-related phenotype. This may improve the ability of researchers to detect genes associated with this subgroup. The identification of biological signatures of specific autism-related immune abnormalities may shed light on the cause(s) of autism in this subgroup and potentially lead to prevention or treatment strategies prior to or during pregnancy.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

267750

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 3LC. Determine the effect of at least five environmental factors on the risk for subtypes of ASD in the pre- and early postnatal period of development by 2015. IACC Recommended Budget: $25,100,000 over 7 years.

Project Link

Project Link

Gene expression and immune cell function in mothers of children with autism (External web link)

Institution

Institution

University of California, Davis

State/Country

State/Country

California

Project Number

Project Number

1R21HD065269-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Gene expression and immune cell function in mothers of children with autism | 267895 | 2010 | 5R21HD065269-02

 
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