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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The brain genomics superstruct project

Principal Investigator

Principal Investigator

Buckner, Randy L.

Description

Description

Randy Buckner and his colleagues hypothesize that genetic predisposition to autism occurs when brain development is steered down an abnormal path through the combined influence of dozens — or even hundreds — of common variations, each with a small role. Researchers will attempt to determine the role of such variations in autism by first attempting to understand their role in typical development. They will collect saliva samples from 1,000 typically developing people, as well as data from a recently developed imaging tool called functional connectivity magnetic resonance imaging, or (fcMRI). This tool allows researchers to examine basic properties of brain organization and link differences in these properties to specific genetic variants. Buckner and colleagues have dubbed their effort the Brain Genomics Superstruct Project, as it builds on, or "superstructs," the collective foundation laid by previous work on autism. Because the complex studies linking genetics and brain function will require the effort of many research groups, the researchers plan to share their data collection, which will eventually include 5,000 people. The team will also share their rapid fcMRI protocol, which eases the burden of data acquisition by capturing imaging data in less than 15 minutes per subject.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

75000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

The brain genomics superstruct project (External web link)

Institution

Institution

President & Fellows of Harvard College

State/Country

State/Country

Massachusetts

Project Number

Project Number

137319

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The Brain Genomics Superstruct Project | 0 | 2011 | 205055
The Brain Genomics Superstruct Project | 150000 | 2012 | 205055
The Brain Genomics Superstruct Project | 150000 | 2013 | 205055
The brain genomics superstruct project | 150000 | 2010 | 137319
The brain genomics superstruct project | 75000 | 2011 | 137319

 
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