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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

The role of SHANK3 in autism spectrum disorders

Principal Investigator

Principal Investigator

Buxbaum, Joseph

Description

Description

Disruptions in the SHANK3 gene have been shown to result in autism. Joseph Buxbaum and his colleagues have created a mouse model with a similar disruption in SHANK3. The researchers plan to use this model to test their hypothesis that interfering with the expression of SHANK3 disrupts the connections between neurons, leading to overall developmental delays that ultimately result in autism. A team of five laboratories will use the mouse model to study autism from a variety of perspectives. Buxbaum and his laboratory plan to study the regulation and biochemical properties of SHANK3. Patrick Hof plans to look at changes in the morphology and distribution of neurotransmitter receptors in neurons brought on by disrupting SHANK3. Qiang Zhou aims to record electrical currents from the mouse neurons, a measure of their function, and investigate whether neuronal communication is abnormal in the mice. Finally, Jacqueline Crawley at the National Institute of Mental Health plans to evaluate the ability of the mice to learn and to interact socially, behaviors that are analogous to those altered in people with autism. The researchers hope this multi-pronged approach will provide a well-rounded understanding of the role of SHANK3 — and neurotransmitter biology in general — in the development of autism.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

360000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 4: Which Treatments And Interventions Will Help?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 4SB. Standardize and validate at least 20 model systems (e.g., cellular and/or animal) that replicate features of ASD and will allow identification of specific molecular targets or neural circuits amenable to existing or new interventions by 2012. IACC Recommended Budget: $75,000,000 over 5 years.

Project Link

Project Link

The role of SHANK3 in autism spectrum disorders (External web link)

Institution

Institution

Mount Sinai School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

94982

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

The role of SHANK3 in autism spectrum disorders | 360000 | 2010 | 94982
The role of SHANK3 in autism spectrum disorders | 180000 | 2011 | 94982
The role of SHANK3 in autism spectrum disorders | 0 | 2012 | 94982
The role of Shank3 in autism spectrum disorders | 360000 | 2008 | Project number unavailable

 
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