Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Genome-wide analyses of DNA methylation in autism

Principal Investigator

Principal Investigator

Chess, Andrew

Description

Description

Andrew Chess and his colleagues are exploring a new way by which polymorphisms (small variations in the DNA sequence of a gene) can control gene regulation by influencing the addition of methyl groups to the DNA strand, impeding its expression. The researchers plan to explore whether and how a mechanism involving polymorphisms and methylation might be at work in autism. To analyze methylation across the genome, the researchers digest the entire genome using special enzymes that break the DNA strand at all potential methylation sites, except those that are actually methylated. The remaining DNA fragments can then be analyzed to determine which polymorphisms they represent. Chess and his team plan to use this technique to look for differences in methylation patterns between individuals with autism and healthy controls. They also plan to analyze identical twin pairs in which only one twin has autism in the hopes of uncovering a reason for the difference. The findings may lead to the discovery of genes that cause autism when their expression is altered by methylation.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

400000

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Genome-wide analyses of DNA methylation in autism (External web link)

Institution

Institution

Massachusetts General Hospital

State/Country

State/Country

Massachusetts

Project Number

Project Number

95349

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Genome-wide analyses of DNA methylation in autism | 400000 | 2010 | 95349
Genome-wide analyses of DNA methylation in autism | 400000 | 2008 | Project number unavailable
Genome-wide analyses of DNA methylation in autism | 200000 | 2011 | 95349
Genome-wide analyses of DNA methylation in autism | 60000 | 2012 | 95349
Genome-wide analyses of DNA methylation in autism | 0 | 2013 | 95349

 
Back to Top