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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Quantitative analysis of craniofacial dysmorphology in autism

Principal Investigator

Principal Investigator

Deutsch, Curtis

Description

Description

Craniofacial anomalies could plausibly be prevalent among people with a brain-based disorder because of the shared developmental heritage of face and brain. The brain, head, and face form from common embryonic areas and are shaped by shared developmental mechanisms, so a genetic or environmental insult that disrupts early development could affect both brain and craniofacial formation. Dr. Deutsch and colleagues will use a two-pronged approach to ascertain the relationship between craniofacial anomalies and autism. First, with a technique called stereophotogrammetric imaging, the researchers will capture a three-dimensional image of a participant's face and head and then use computer software to obtain detailed measurements. The researchers will then compare measurements recorded from people with autism with those previously documented from the general population, to analyze how far the former deviate from the norm. The team will focus on combinations of anomalies, such as those with similar embryonic origins, and they will determine whether the occurrence of these biologically interpretable combinations is associated with behavioral phenotypes and specific genetic variations. The researchers will also look for clusters of craniofacial anomalies that could help distinguish among subtypes of autism.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

68688

Current Award Period

Current Award Period

na

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1SA. Develop, with existing tools, at least one efficient diagnostic instrument (e.g., briefer, less time intensive) that is valid in diverse populations for use in large-scale studies by 2011. IACC Recommended Budget: $5,300,000 over 2 years.

Project Link

Project Link

Quantitative analysis of craniofacial dysmorphology in autism (External web link)

Institution

Institution

University of Massachusetts Medical School

State/Country

State/Country

Massachusetts

Project Number

Project Number

137390

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Quantitative analysis of craniofacial dysmorphology in autism | 137861 | 2010 | 137390
Quantitative analysis of craniofacial dysmorphology in autism | 69173 | 2011 | 137390

 
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