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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Translational developmental neuroscience of autism

Principal Investigator

Principal Investigator

Di Martino, Adriana

Description

Description

This is a mentored Research Career Development Award to support the career development of clinical investigators in patient-oriented research. Cortico-cortical functional connectivity (FC), defined as the temporal correlations between remote neurophysiological events, has not been systematically studied in children and adolescents with autism. As a first step towards understanding how brain functional connectivity develops in autism, this study will examine the cross-sectional development of FC of the pregenual anterior cingulate cortex (pgACC) in children and adolescents using functional magnetic resonance imaging (fMRI). This network was selected because of its involvement in social processes, preliminary reports of structural and functional abnormalities in autism, and its prolonged maturational course. The hypothesis of this work is that the derangements in FC within the pgACC network in autism reflect a fundamental failure of brain maturation and that social impairment in autism can be directly related to abnormal pgACC connectivity. Brain functional connectivity will be examined in 40 male children and adolescents with high-functioning autism (HFA) compared to equal numbers of healthy controls. The aims are to use resting state fMRI to examine differences in short- and long-range FC in the pgACC network, to test the relationship between social impairment and measures of short- and long-range FC in the pgACC network, and to examine the rates of age-related decreases in short-range FC and age-related increases in long-range FC in the pgACC network. This project has the potential to inform understanding of the neural bases of autism, which is needed to improve early identification, refine diagnostic assessments, and yield novel treatments.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

143617

Current Award Period

Current Award Period

2010-2013

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1LB. Develop at least five measures of behavioral and/or biological heterogeneity in children or adults with ASD, beyond variation in intellectual disability, that clearly relate to etiology and risk, treatment response and/or outcome by 2015. IACC Recommended Budget: $71,100,000 over 5 years.

Project Link

Project Link

Translational developmental neuroscience of autism (External web link)

Institution

Institution

New York University School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

1K23MH087770-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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