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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Biomarkers and diagnostics for ASD

Principal Investigator

Principal Investigator

Bahn, Sabine

Description

Description

The diagnosis of autistic spectrum disorder (ASD) is subjective because of the complex spectrum of symptoms and the lack of empirical markers. This is due to the fact that little is known about the basic mechanisms underlying the etiology and progression of the condition. However, there is widespread agreement that early diagnosis and appropriate intervention can lead to a better outcome for the affected individual and their families. This study will attempt to identify a serum-based panel of biomarkers for minimally-invasive early diagnosis of ASD and potentially for distinguishing the various subtypes of the condition using state-of-the-art proteomic platforms. The investigators have already identified a prototype panel using the Multi-Analyte Profiling (xMAP®) platform which can distinguish Asperger's subjects from matched controls in a small clinical cohort. They propose to develop this panel further through profiling analyses of additional cohorts reflecting the spectrum of the condition compared to age and gender matched controls. The second phase of the project will test the prototype panel using larger clinical cohorts to identify the most robust biomarker patterns for identification of ASD subtypes at the earliest possible clinical phase. The resulting panels will be deployed using the xMAP® format for maximum utility and ease of use in the clinical setting. The availability of biomarker panels for ASD promises to lead to: 1) increased understanding of the underlying molecular mechanisms, 2) earlier diagnosis of affected individuals, 3) positioning of subjects for early intervention approaches and 4) identification of potentially novel treatment strategies.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

149600

Current Award Period

Current Award Period

2010-2013

Strategic Plan Question

Strategic Plan Question

Question 1: When Should I Be Concerned?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 1SA. Develop, with existing tools, at least one efficient diagnostic instrument (e.g., briefer, less time intensive) that is valid in diverse populations for use in large-scale studies by 2011. IACC Recommended Budget: $5,300,000 over 2 years.

Project Link

Project Link

Biomarkers and diagnostics for ASD (External web link)

Institution

Institution

Institute of Biotechnology

State/Country

State/Country

United Kingdom

Project Number

Project Number

6009

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Biomarkers and diagnostics for ASD | 149600 | 2011 | 6009
Biomarkers and diagnostics for ASD | 149600 | 2012 | 6009
Biomarkers and diagnostics for ASD | 0 | 2013 | 6009

 
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