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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders

Principal Investigator

Principal Investigator

Kleinhans, Natalia

Description

Description

In the present study, researchers will test the hypothesis that early changes in brain growth in autism has long-term consequences for neural connectivity, or communication between different regions of the brain, as changes in connectivity are thought to underlie the symptoms of autism. Dr. Kleinhans and colleagues will examine this proposed relationship between early brain growth and later brain connectivity. They will gather previously collected measurements of brain size and volume from 3 to 5 year old children with low-functioning autism. When these children are 15 years old, they will be asked to participate in a brain imaging study using functional magnetic resonance imaging (fMRI), a non-invasive method of imaging patterns of brain activity and neural connectivity. These data should determine whether an increase in brain size during childhood is correlated with weakened or changed patterns of connections between brain regions in teenagers with autism and contribute to the understanding of the developmental basis of behavioral impairment and clinical outcomes in autism spectrum disorders.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

103062

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LA. Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.

Project Link

Project Link

Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders (External web link)

Institution

Institution

University of Washington

State/Country

State/Country

Washington

Project Number

Project Number

3628

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders | 124816 | 2009 | 3628
Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders | 120000 | 2008 | 3628
Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders | 117156 | 2011 | 3628
Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders | 0 | 2012 | 3628

 
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