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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Pragmatic skills of young males and females with fragile X syndrome (supplement)

Principal Investigator

Principal Investigator

Martin, Gary

Description

Description

The use of language in social contexts, or pragmatic skills, are essential for daily communication. This study compares the developmental trajectories of these skills. Determining whether a pragmatic skill is either unique to fragile X syndrome (FXS) or related to other conditions, such as gender, mental retardation, or autism, may help in defining treatment options for fragile X in males. In this study, children's pragmatic skills, including their initiations, contingency, perseveration, and repair strategies during conversation and their informativeness and cohesiveness during narration will be assessed annually for four years. Children's language content and structure, cognition, social-emotional behavior (anxiety and autistic characteristics), and family environment will also be examined annually. In addition, Fragile X Mental Retardation Protein (FMRP) analysis from blood samples will be completed on the girls and boys with FXS. These studies may indicate a unique pragmatic phenotype for FXS.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

125116

Current Award Period

Current Award Period

2010-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2LA. Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people by 2020. IACC Recommended Budget: $126,200,000 over 12 years.

Project Link

Project Link

Pragmatic skills of young males and females with fragile X syndrome (supplement) (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

3R01HD038819-09S1

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Pragmatic skills of young males and females with fragile X syndrome | 517519 | 2009 | 5R01HD038819-08
Pragmatic skills of young males and females with fragile X syndrome | 507009 | 2010 | 5R01HD038819-09
Pragmatic skills of young males and females with fragile X syndrome | 517218 | 2008 | R01HD038819-07

 
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