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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Architecture of myelinated axons linking frontal cortical areas

Principal Investigator

Principal Investigator

Barbas, Helen

Description

Description

This research project will pinpoint the structural factors that contribute to the enlargement of white matter in the prefrontal cortex in autism. Dr. Barbas' fellow will examine post-mortem tissue from autistic and control individuals for differences in axon density, axon size, myelination, and number of non-neuronal cells that surround axons ("glia"). A second goal of this project is to develop the use of non-invasive imaging of white matter so that future studies will not have to rely on post-mortem tissue. As a first step, the prefrontal pathways in rhesus monkeys will be mapped. These pathways will initially be scanned using non-invasive diffusion tensor imaging (DTI); subsequently, these pathways will be labeled via injections of tracers into the same brains. Information from both DTI and tracer injections will then be compared to help optimize non-invasive scanning and image analysis protocols for future use in humans.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

Architecture of myelinated axons linking frontal cortical areas (External web link)

Institution

Institution

Boston University

State/Country

State/Country

Massachusetts

Project Number

Project Number

2156

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Architecture of myelinated axons linking frontal cortical areas | 54000 | 2009 | 2156
Architecture of myelinated axons linking frontal cortical areas | 54000 | 2008 | 2156
Architecture of myelinated axons linking frontal cortical areas | 0 | 2011 | 2156

 
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