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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls

Principal Investigator

Principal Investigator

Barnea-Goraly, Naama

Description

Description

Several structural brain abnormalities have been associated with autism, but none have been consistently replicated, and no single abnormality is seen in all persons with autism. A potential factor contributing to these inconsistencies is the inherent difficulty in controlling for genetic and environmental variables that influence brain development. To overcome this difficulty, Dr. Barnea-Goraly will compare brain structure in siblings discordant for autism (sibling pairs in which one has autism and the other does not). This design minimizes genetic and environmental differences that could influence brain morphology. The study will use an innovative analysis of brain-surface complexity in individuals with autism, their non-autistic siblings, and in control subjects to examine the relationship between brain structure and autism. The study will also assess brain-surface complexity in very young subjects with autism (23-43 months of age) as compared to age- and gender-matched control subjects. This very young population will allow investigation of brain structure at the earliest ages in which autism diagnosis is possible. In addition, measures of brain-surface complexity will be compared to behavioral features of subjects with autism.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

100000

Current Award Period

Current Award Period

2008-2010

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls (External web link)

Institution

Institution

Stanford University

State/Country

State/Country

California

Project Number

Project Number

2319

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls | 0 | 2009 | 2319
Investigation of cortical folding complexity in children with autism, their autism-discordant siblings, and controls | 100000 | 2008 | 2319

 
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