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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Engrailed and the control of synaptic circuitry in drosophila

Principal Investigator

Principal Investigator

Blagburn, Jonathan

Description

Description

Engrailed is a transcriptional regulator that has recently been linked to fate determination and survival of midbrain dopaminergic neurons. Engrailed (En) knockout mice have shown Parkinson-like symptoms, and En has also been linked to autism spectrum disorder. The objective of this research is to use drosophila (fruit fly), a simple model system that has identifiable neurons, to investigate the role En plays in regulating neuronal connectivity. Specifically, this research will focus on how En controls synaptic target recognition and identify the downstream effector genes that it regulates. Drosophila models are particularly useful for the discovery of molecular pathways that are directly relevant to human health because most of these pathways have been conserved during evolution. All animals have Engrailed protein, so it is very likely that any molecules that are regulated by it during the process of synapse formation in Drosophila have their counterparts in humans. These molecules may be of great potential importance in neurological diseases, such as Parkinson's or autism.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

112500

Current Award Period

Current Award Period

2008-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

2O. Not specific to Question 2 objectives

Project Link

Project Link

Engrailed and the control of synaptic circuitry in drosophila (External web link)

Institution

Institution

University of Puerto Rico Medical Sciences Campus

State/Country

State/Country

Puerto Rico

Project Number

Project Number

5SC2NS065384-03

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Engrailed and the control of synaptic circuitry in Drosophila | 112500 | 2009 | 5SC2NS065384-02
Engrailed and the control of synaptic circuitry in Drosophila | 112500 | 2008 | SC2NS065384-01

 
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