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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Steroid receptors and brain sex differences

Principal Investigator

Principal Investigator

Auger, Anthony

Description

Description

This study investigates the functional role of ligand-independent activation of estrogen receptors (ER) in the developing brain. Recent data indicate that acute changes in dopamine transmission during the first few days of life can dramatically alter the developmental organization of social play behavior by activating ER in a ligand-independent manner. As social play behavior is dramatically disrupted in children with autism and Asperger's syndrome, and social play behavior in rodents has been used as a rodent model for the study of autism, it is possible that these data will further understanding of how sexually dimorphic social disorders occur during brain development.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

301240

Current Award Period

Current Award Period

2006-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.

Project Link

Project Link

Steroid receptors and brain sex differences (External web link)

Institution

Institution

University of Wisconsin - Madison

State/Country

State/Country

Wisconsin

Project Number

Project Number

5R01MH072956-05

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Steroid receptors and brain sex differences | 301301 | 2009 | 5R01MH072956-04
Steroid receptors and brain sex differences | 301359 | 2008 | R01MH072956-03

 
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