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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Investigation of sex differences associated with autism candidate gene, CYFIP1

Principal Investigator

Principal Investigator

Werling, Donna

Description

Description

This is an individual National Research Service Award for pre-doctoral research training, which provides support for promising doctoral candidates who will be performing dissertation research and training in a scientific health-related field. Continued identification of genes associated with ASDs has advanced understanding of the role of genetics in ASDs, but the skewed sex ratio in prevalence remains unexplained. To this end, studying a candidate gene that shows sex differences in expression patterns or associated neural phenotypes may provide unique insights into ASD pathophysiology. Data from the Geschwind lab show that cytoplasmic FMRP-interacting protein 1 (CYFIP1) expression patterns differ by sex and that neuropathological phenotypes associated with Cyfip1 over-expression may also show sex differences. CYFIP1 has also been implicated in neural development and function, making this candidate gene a unique target for study. A transgenic mouse model that over-expresses Cyfip1 will be used to better understand the implications of the sex differences in Cyfip1 expression in neural development and ASD pathophysiology. Continued investigation along these lines will accelerate identification of those factors that cause males to be vulnerable to, or females to be protected from, ASDs, thereby facilitating the development of pharmaceutical treatments and preventive measures for ASDs.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

31561

Current Award Period

Current Award Period

2010-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.

Project Link

Project Link

Investigation of sex differences associated with autism candidate gene, CYFIP1 (External web link)

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

1F31MH093086-01

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

N/A

 
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