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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A sex-specific dissection of autism genetics

Principal Investigator

Principal Investigator

Weiss, Lauren

Description

Description

Autism spectrum disorders are among the most heritable common disorders and show extensive clinical heterogeneity, however, both the underlying neurobiological basis and genetic architecture are poorly understood. Four times as many males as females are affected, for unknown reasons. Knowledge about the primary genetic and hormonal determinants of sexual dimorphism may be able to be leveraged in order to dissect a major source of heterogeneity in autism. The objective of this proposal is to investigate genetic causes for increased male risk of autism. Guided by preliminary data including sex-specific genetic contributors to autism and extensive sexually dimorphic genetic architecture for numerous human traits, this proposal comprises a pilot study to recruit subjects, including an enriched female-affected family sample, and compare males and females in order to identify sex-specific susceptibility genes. The results will be significant, as information about what protects females from developing autism could lead to reduction of male risk. The long-term goal is to use genetic tools to better understand the biological basis of autism, leading to advances in diagnosis, prevention and treatment.

Funder

Funder

Simons Foundation

Fiscal Year Funding

Fiscal Year Funding

150000

Current Award Period

Current Award Period

2009-2012

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Yellow dot: Objective has some degree of funding, but less than the recommended amount. 2SB. Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5 years.

Project Link

Project Link

A sex-specific dissection of autism genetics (External web link)

Institution

Institution

University of California, San Francisco

State/Country

State/Country

California

Project Number

Project Number

137620

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

A sex-specific dissection of autism genetics | 270375 | 2009 | 1R21HD065273-01
A sex-specific dissection of autism genetics | 75000 | 2009 | 137620
A sex-specific dissection of autism genetics | 270375 | 2010 | 5R21HD065273-02
A sex-specific dissection of autism genetics | 150000 | 2011 | 137620
A sex-specific dissection of autism genetics | 0 | 2012 | 137620

 
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