The most common known genetic cause of autism is Fragile X Syndrome. Fragile X Syndrome is caused by the loss of expression in the brain of the Fragile X Mental Retardation Protein, abbreviated FMRP. In humans, there are multiple other proteins that are closely related to FMRP that are expressed in the brain. These proteins are similar in structure to FMRP, and we hypothesize that higher expression of one of them in the brain could ameliorate the effects of FMRP loss. We will carry out experiments to explore this hypothesis. The function of FMRP is to bind a specific set of messenger RNAs and regulate their translation into proteins. First, we will determine which FMRP-related proteins bind similar messenger RNAs as FMRP. Second, we will screen in a high-throughput assay for drugs that increase the levels of the protein that is most similar in function to FMRP. These experiments, if successful, may lead to a new treatment strategy for Fragile X syndrome, with implications for other autism spectrum disorders.