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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

A longitudinal MRI study of brain development in fragile X syndrome

Principal Investigator

Principal Investigator

Hazlett, Heather

Description

Description

The proposed research will conduct a magnetic resonance imaging (MRI) study of very early brain and behavior development at 6, 12, and 24 months in infants with fragile X syndrome (FXS) using MRI and diffusion tensor imaging (DTI). The study will examine how the path and growth of brain development in infants with FXS compares to early brain development in infants at high-risk for autism [who later develop autism spectrum disorder (ASD)] as well as typically developing infants. It will also assess the trajectory of early post-natal brain overgrowth in FXS, as measured on MRI and DTI, and its potential relationship to clinical features, particularly those features characteristic of ASD. This study has the potential to distinguish specific behavioral, genetic, and neurobiological features that characterize infants with FXS in comparison with infants at high-risk for autism and those with typical development.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

617080

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SD. Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

A longitudinal MRI study of brain development in fragile X syndrome (External web link)

Institution

Institution

University of North Carolina at Chapel Hill

State/Country

State/Country

North Carolina

Project Number

Project Number

5R01HD059854-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

A longitudinal MRI study of brain development in fragile X syndrome | 622099 | 2009 | 1R01HD059854-01A1

 
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