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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Relation of sleep epileptiform discharges to insomnia and daytime behavior

Principal Investigator

Principal Investigator

Barnes, Gregory

Description

Description

Children with autism spectrum disorders (ASD) are known to have a higher prevalence of epilepsy and sleep disturbances, which may affect daytime functioning. Interictal epileptiform discharges (IEDs) are patterns of abnormal brain activity associated with epilepsy which have also been found to be prevalent in people with ASDs. Whether IEDs are involved in sleep disturbance in children with ASD is unknown, and this proposed study is aimed at examining potential links between IEDs, sleep, and behavior. Researchers will test the hypothesis that IEDs during sleep may affect sleep patterns, contributing to the underlying sleep disturbance which may in turn result in behavioral problems. Dr. Barnes and colleagues will examine the prevalence of IEDs during sleep in a cohort of children with ASD. IEDs are measured by electroencephalography (EEG), which records electrical activity in the brain in a noninvasive manner. EEG and behavioral data will be used to examine the relationships between sleep IEDs, sleep disturbances, and daytime behavior in these children.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2009-2010

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Relation of sleep epileptiform discharges to insomnia and daytime behavior (External web link)

Institution

Institution

Vanderbilt University

State/Country

State/Country

Tennessee

Project Number

Project Number

3689

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Relation of sleep epileptiform discharges to insomnia and daytime behavior | 60000 | 2009 | 3689
Relation of sleep epileptiform discharges to insomnia and daytime behavior | 60000 | 2008 | 3689

 
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