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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Molecular components of A-type K+ channels

Principal Investigator

Principal Investigator

Rudy, Bernardo

Description

Description

This project investigates the relevance of newly discovered components of ion channels in brain neurons that are important in learning, pain control, and the pathogenesis of epilepsy and autism. Fast transient potassium currents, such as those found in neurons and cardiac cells, are essential for the proper functioning of the brain and the heart. During pathological conditions, abnormalities in these currents can contribute to disease conditions. This project addresses the molecular nature of the ion channels responsible for the generation of these currents in mammalian neurons, using both cellular and mouse models. It seeks to establish the molecular composition of these channels and to elucidate the physiological significance of the identified components.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

349013

Current Award Period

Current Award Period

2009-2014

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SE. Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Link

Project Link

Molecular components of A-type K+ channels (External web link)

Institution

Institution

New York University School of Medicine

State/Country

State/Country

New York

Project Number

Project Number

5R01NS045217-07

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Molecular components of A-type K+ channels | 352538 | 2009 | 2R01NS045217-06A1

 
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