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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Neural and phenotypic correlates of autism risk genes

Principal Investigator

Principal Investigator

Bookheimer, Susan

Description

Description

This project aims to understand variability in the autism phenotype by examining links between known genetic risk factors for autism and brain structure and function. Eighty children with autism and 40 controls will undergo a comprehensive phenotyping assessment, high field structural magnetic resonance imaging (MRI), and functional MRI using three tasks that differentiate typically developing children from those with autism. This study will focus on five autism risk polymorphisms and one known genetic syndrome, 22q11deletion, with the goal of identifying structural and functional brain abnormalities that are linked to autism risk polymorphisms and in turn to link these neural anomalies to variations in the autism phenotype. Profiles of imaging phenotypes in autism will be developed that will help identify valid autism subtypes based on brain structure and function, and these phenotypes will be linked to their genetic origins.

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

545057

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 2: How Can I Understand What Is Happening?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 2SG. Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.

Project Link

Project Link

Neural and phenotypic correlates of autism risk genes (External web link)

Institution

Institution

University of California, Los Angeles

State/Country

State/Country

California

Project Number

Project Number

5R01HD065280-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Neural and phenotypic correlates of autism risk genes | 545057 | 2009 | 1R01HD065280-01

 
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