Skip to content
Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Gene expression profiling of autism spectrum disorders

Principal Investigator

Principal Investigator

Collins, Christin

Description

Description

Autism spectrum disorders (ASD) are likely caused by interactions between genetic and environmental factors which result in changes in neural development and activity. Identifying reproducible changes in gene expression levels in individuals with ASD would be a valuable tool, both for understanding the molecular basis of these disorders and in developing earlier and more accurate diagnostic tests. Dr. Collins will examine gene expression profiles in individuals with ASD using microarray technology, a technique used to measure the levels of expression of thousands of genes simultaneously. Gene expression in peripheral blood from ASD patients will be compared to that of healthy controls, and genes expressed at either higher or lower levels in the ASD patients will be identified. This approach may identify novel genes which are misregulated in autism, as well as provide the basis for the development of newer, more sensitive diagnostic tools for this disorder.

Funder

Funder

Autism Speaks

Fiscal Year Funding

Fiscal Year Funding

0

Current Award Period

Current Award Period

2008-2010

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LB. Identify genetic risk factors in at least 50% of people with ASD by 2014. IACC Recommended Budget: $33,900,000 over 6 years.

Project Link

Project Link

Gene expression profiling of autism spectrum disorders (External web link)

Institution

Institution

Children's Hospital Boston

State/Country

State/Country

Massachusetts

Project Number

Project Number

4828

Federal or Private?

Federal or Private?

Private

Received ARRA Funding?

Received ARRA Funding?

No

History/Related Projects

History/Related Projects

Gene expression profiling of autism spectrum disorders | 52000 | 2009 | 4828
Gene expression profiling of autism spectrum disorders | 51000 | 2008 | 4828

 
Back to Top