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Interagency Autism Coordinating Committee (IACC)
Autism Research Database
Office of Autism Research Coordination (OARC)
 
Project Element Element Description

Project Title

Project Title

Investigating gene-environment interaction in autism: Air pollution x genetics

Principal Investigator

Principal Investigator

McConnell, Rob

Description

Description

While genetic risk factors are widely implicated in ASDs, the current increase in prevalence is not likely to result from genetic factors alone and it is possible that environmental factors may augment known genetic risks. In this study, researchers seek to examine if air pollution due to traffic, a common environmental exposure, increases risk for ASD. Using data collected as part of the Childhood Autism Risks from Genetics and the Environment Study (CHARGE), researchers will assess the role of traffic related air pollutants in autism risk based on monthly exposure at each child's home during prenatal, perinatal, and postnatal time points. Researchers will also examine genes that process pollutants in the body to determine if they are different in children with and without autism and to see if these genes interact with air pollution to increase autism risk. This work may provide important insight into what causes ASDs and evidence for risk due to a common environmental exposure (traffic-related air pollution).

Funder

Funder

National Institutes of Health

Fiscal Year Funding

Fiscal Year Funding

280078

Current Award Period

Current Award Period

2009-2011

Strategic Plan Question

Strategic Plan Question

Question 3: What Caused This To Happen And Can This Be Prevented?

Strategic Plan Objective

Strategic Plan Objective

Green dot: Objective has greater than or equal to the recommended funding. 3LD. Support ancillary studies within one or more large-scale, population-based surveillance and epidemiological studies, including U.S. populations, to collect data on environmental factors during preconception, and during prenatal and early postnatal development, as well as genetic data, that could be pooled (as needed), to analyze targets for potential gene/environment interactions by 2015. IACC Recommended Budget: $44,400,000 over 5 years.

Project Link

Project Link

Investigating gene-environment interaction in autism: Air pollution x genetics (External web link)

Institution

Institution

University of Southern California

State/Country

State/Country

California

Project Number

Project Number

5R21ES019002-02

Federal or Private?

Federal or Private?

Federal

Received ARRA Funding?

Received ARRA Funding?

Yes

History/Related Projects

History/Related Projects

Investigating gene-environment interaction in autism: Air pollution X Genetics | 297117 | 2009 | 1R21ES019002-01

 
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